A Microsoft Patch recently released breaks vSphere client functionality. If you receive the following error while trying to connect to vCenter:

<strong>Could Not Connect: Error parsing the server "<em>insert your virtual center server"</em> "clients.xml" file. Login will continue, contact your system administrator.</strong>

Then you'll want to read below to quicly get back on track.

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Go to your vCenter server and go to add/remove programs, remove KB980773, this is recently released Microsoft Patch for .NET that results in that results in the break. Remove the Microsoft Patch and you're all set.

 

No reboot necessary.