I ran into this issue today (unable to successfully save and close and outlook 2010 appointment), and after researching in the internet I came up with nothing.

After some troubleshooting I was able to resolve the issue. Here's how.

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For me the issue boiled down creating the appointment on my DroidX. With corporate sync enabled, then appointment quickly showed up in my Outlook client. From my outlook client this is where I ran into the issue. For me deleting the meeting and creating a new appointment via Outlook solved my problem as the  <strong>outlook.exe /resetnavpane </strong>had no effect.

If you run into this issue, just delete and start fresh and save yourself the time. Hopefully this issue is just an anomally.