Using Update Manager 4.0 Update 1, you can now install PowerPath/VE to ESX/ESXi 4.0 hosts. For those who haven't seen the previous installation method, it was a little bit too "involved" for my liking--

This <a href="http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&amp;cmd=displayKC&amp;externalId=1018740" target="_blank">VMware KB </a> article explains the process-- let us know how it goes for you!